Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog (NCT06614309) | Clinical Trial Compass
RecruitingNot Applicable
Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog
United States45 participantsStarted 2024-09-24
Plain-language summary
This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria:
* English speaking
* Diagnosis of Long COVID
Exclusion criteria:
* Any history of:
* Coronary artery dissection or aortic dissection
* Neurological disease (e.g. dementia, Alzheimer's disease, or other brain-related disease)
* Cerebrovascular disease or stroke
* Aneurysm
* If currently has:
* Moderate-severe chronic obstructive pulmonary disease
* Uncontrolled moderate-severe asthma
* Moderate-severe bronchiectasis
* Moderate-severe interstitial lung disease, requiring the use of supplemental oxygen
* A necessity to use supplemental oxygen, for any reason
* New or worsening symptoms (decompensation) of heart failure
* Right heart disease due to chronic pulmonary disease/sleep apnea
* Uncontrolled myocardial ischemia or angina
* Uncontrolled heart arrhythmias
* Heart or lung infection (e.g. myocarditis or pericarditis)
* Left main coronary artery stenosis
* Moderate-severe aortic stenosis
* Pulmonary embolism, pulmonary infarction, or other blood clots
* Severe respiratory disease
* Chronic kidney disease
* Chronic liver disease
* Females of childbearing potential will complete a urine pregnancy test at their baseline visit to rule out pregnancy
* BMI \>40
* Study staff unable to obtain adequate signal for cerebral blood flow
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is measuring changes in cerebral blood flow and heart rate variability as its main outcomes — can you help me understand what those measurements tell us about whether my brain fog is actually improving, and whether those are good markers for Long COVID recovery?
2Since this trial is listed as Phase NA, which often means it's a very early feasibility or pilot study, what does that mean for how much we'd know about safety and effectiveness before I'd be participating?
3The trial uses a non-invasive treatment — do you know what that specific intervention is, and are there any risks or side effects I should be aware of even if it's described as non-invasive?
4Given that my brain fog is already affecting my daily life, would it make more sense to try established management strategies first before joining a trial where outcomes are still being measured and aren't guaranteed?
5What would participation actually look like in terms of appointments, monitoring, and time commitment, and is that realistic given how my Long COVID symptoms affect my ability to travel or maintain a schedule?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in cerebral blood flow
Timeframe: Baseline, post-acute exposure and 14 days post training
2
Change in heart rate variability
Timeframe: Baseline, post-acute exposure and 14 days post training
3
Change in brain fog scale
Timeframe: Baseline, post-acute exposure and 14 days post training