Ultrasound Assessment During Weaning from Mechanical Ventilation (NCT06609798) | Clinical Trial Compass
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Ultrasound Assessment During Weaning from Mechanical Ventilation
Argentina429 participantsStarted 2024-06-10
Plain-language summary
The ECO-WEANING study aims to improve the process of safely removing patients from mechanical ventilation in the Intensive Care Unit (ICU). Some patients have difficulty breathing on their own after being on a ventilator, which can lead to longer hospital stays and complications. This study will use ultrasound to assess lung, heart, and diaphragm function before removing the ventilator. Combining these ultrasound results, we hope to identify better patients at high risk of needing mechanical ventilation again. The goal is to help guide care decisions and improve recovery, reducing the need for re-intubation or other interventions.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients (18 years or older).
* Receiving mechanical ventilatory assistance for more than 48 hours.
* The patient is deemed ready to undergo a Spontaneous Breathing Trial, as determined by the attending physician.
* Ultrasound measurements are performed between 20 and 30 minutes after the initiation of the trial.
Exclusion Criteria:
* Patients with known or diagnosed neuromuscular disease.
* Limitation of therapeutic effort
* History of severe valvulopathy, severe coronary artery disease, known left ventricular ejection fraction \<35%, or known grade 3 diastolic dysfunction, or who are considered candidates for tracheostomy due to their severity.
* History of home ventilatory support
* Patients who do not have a good acoustic window or have any type of limitation to perform pulmonary, cardiac, or diaphragmatic ultrasound.
* Patients who at the discretion of the treating medical team cannot be placed on a T-tube.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
To develop a predictive model for extubation failure using lung ultrasound, echocardiography, and diaphragmatic parameters
Timeframe: The primary outcome assessment period comprises the first 48 hours after extubation.