The Incidence of Pulmonary, Cardiovascular and Renal System Non-communicable Complications Associ… (NCT06608849) | Clinical Trial Compass
RecruitingNot Applicable
The Incidence of Pulmonary, Cardiovascular and Renal System Non-communicable Complications Associated With the Post-acute Phase of the Infection by Covid-19
Greece345 participantsStarted 2024-12-10
Plain-language summary
More than 660 million cases of COVID-19 have been reported worldwide, with 183 million cases in the EU alone. In several people, after recovery, the effects of the first waves of COVID-19 persisted beyond the acute phase and increased the risk of chronic multiorgan symptoms and disease. Up to 70% of people affected by COVID-19 showed reduced organ function even four months or more after COVID-19 diagnosis. Such a functional decline is associated with an increased risk of the development of non-communicable diseases (NCDs). Thus, there is an essential need for a better knowledge, tools, clinical guidelines and recommendations that it will make it possible to reduce this overrepresentation of NCDs as a consequence of the post-acute phase (PAP) of COVID-19.
The overall concept underpinning "POINT" is to i) build detailed knowledge on the link between the PAP of COVID-19 caused by previous, current, and future SARS-CoV-2 variants in vaccinated and unvaccinated people, and NCDs, ii) identify robust biomarkers and build predictive tools that help early identification and management of risk of NCDs, and iii) develop guidelines and recommendations for all parts of the healthcare value chain, allowing best prevention and care acknowledging vulnerability. The investigators will focus on the NCDs affecting pulmonary, cardiovascular and renal systems.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Adults (18 years or more) of both genders
✓. Negative history of acute COVID-19
✓. Adults (18 years or more) of both genders
✓. History of acute COVID-19 hospitalized or non-hospitalized. All cases appearing from start of the pandemic until the last six months may apply
✓. Absence of any current overt organ dysfunction
✓. Absence of signs of any organ dysfunction during acute COVID-19
✓. Adults (18 years or more) of both genders
✓. History of acute COVID-19 hospitalized or non-hospitalized. All cases appearing from start of the pandemic until the last six months may apply
Exclusion criteria
✕. Any other co-existing disorder generating clinical symptoms
✕. Failure to thrive according to the attending physicians
What they're measuring
1
The incidence of any organ dysfunction during the first 48 months among patients of group C compared to group B