The Safety, Tolerability and Preliminary Efficacy of NouvNeu001 for Early-onset Parkinson's Disease

Inclusion Criteria: * Age 18-70 years old, male or female * Able to understand the rationale of the clinical trial and sign informed consent form (ICF) * Diagnosis of Early-onset Parkinson's Disease in accordance with the MDS clinical diagnostic criteria for Parkinson's disease, and the age of onset was ≤50 years old * Medically suitable for neurosurgery under anesthesia and able to participate in Computed Tomography (CT)/Magnetic Resonance Imaging (MRI) scan. * Hoehn-Yahr staging for "off" episodes is 2 to 4 * The MDS-UPDRS-III score in the "off" state \>30, and positive for the Acute Levodopa Challenge Test (ALCT) * Acceptable laboratory test results during screening and prior to transplantation Exclusion Criteria: * Atypical Parkinsonism * Patients who have had previous pallidotomy, striatal or extrapyramidal surgery or other brain surgery; as well as other surgical procedures that are judged by the investigator to affect patient's participation in this study; Patients with surgical contraindications or other neurosurgical contraindications * Patients who have a previous head CT/MRI examination showing cerebral trauma, vascular malformation, hydrocephalus, brain tumor, etc., and patients who have brain imaging abnormalities in the striatum or other brain areas leading to a significantly increased risk for surgery * Patients with a history of severe cardiovascular and cerebrovascular diseases * Patients with a history of malignant tumors * Patients who have received stem…