RecruitingNot Applicable

Genomics and Microbiome Investigation in Cases of Recurrent Pregnancy Losses

Brazil20 participantsStarted 2023-04-14

Plain-language summary

Recurrent pregnancy losses (RPL) are characterized by the occurrence of more than one spontaneous pregnancy loss. It is caused by different known factors, but about half of the cases remain without an explanation. Efforts are being done in the scientific community to solve this cases. In this study, the investigators aim to investigate genetic factors that might predispose to RPL, as well as the influence of the uterine microbiota (microorganisms that normally live in the uterus of women).

Who can participate

SexFEMALE

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Inclusion Criteria: * RPL group: history of at least two spontaneous pregnancy losses, regardless of whether they have living children, and whose etiology for the pregnancy losses was not determined by the care team\'s protocols; * Control group: at least two full-term pregnancies and no history of difficulty getting pregnant, pregnancy loss or other infertility factors. Exclusion Criteria: * RPL group: less than two spontaneous pregnancy losses and those with a known cause for repeated pregnancy losses; * Control group: N/A

What they're measuring

Microbiome

Timeframe: At the time of enrollment

Exome

Timeframe: At the time of enrollment

Trial details

NCT IDNCT06604338

SponsorHospital de Clinicas de Porto Alegre

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-07-05

Contact for this trial

Lucas Rosa Fraga, PhD, Professor

+555133597661 lrfraga@hcpa.edu.br

View on ClinicalTrials.gov More Recurrent Pregnancy Loss(RPL) trials