Parkinson's disease is a neuromuscular disease that is relatively common in elderly that has many potentials symptoms, including a variety of physical features that together reduce quality of life. The Study Team have developed a nutritional supplement (AMS2434) based on essential amino acids that targets improving muscle health and brain neurotransmitter balance. This protocol will determine in individuals with PD the effect of AMS2434 on muscle protein synthesis, neurotransmitter production, and mood and cognition.
Who can participate
Age range
55 Years – 99 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 55 years or older
* Clinical diagnosis of idiopathic Parkinson Disease
* Hoehn and Yahr stage 2-3
* Stable medication regimen with L-DOPA/carbidopa for at least 4 weeks prior to study entry
Exclusion Criteria:
* Findings suggestive of atypical or secondary Parkinsonism, including cerebellar sign
* Use of anticoagulation drugs (including aspirin and Plavix) within one week of the protocol
* Allergy to lidocaine
* Supranuclear gaze palsy, apraxia, prominent autonomic failure, or other cortical signs
* Multiple strokes with stepwise progression of symptoms
* Neuroleptic treatment at time of study entry or time of onset of Parkinsonism
* Inability to walk without a cane or walker
* Deep brain stimulation
* Montreal Cognitive Assessment (MoCA) score \<18
* Use of investigational drugs
* Early Alzheimer's disease
* Frontotemporal dementia of dementia with Lewy bodies
* Major depression treated with SSRIs
* Individuals with auditory or visual hallucinations
* Individuals taking drugs that cause Parkinsonism like symptoms such as antipsychotics, anti-emetics, prokinectic and anti-seizure medications
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.