RecruitingPhase 4

Secondary Prevention of VTE in Patients With Cancer and Catheter-Related Upper Extremity Deep Vein Thrombosis

Canada330 participantsStarted 2024-12-19

Plain-language summary

This trial seeks to evaluate a management strategy after the acute treatment duration (≥ 3 months of therapeutic anticoagulation) for patients with cancer and catheter-related upper extremity deep vein thrombosis (DVT).

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Adult patients (≥ 18 years old) with active cancer, defined as cancer (other than localized non-melanoma skin cancer) diagnosed or treated within 6 months, or the presence of metastatic, recurrent, or progressive malignancy, ongoing anticancer therapy, or hematological malignancy not in complete remission.
✓. Objectively confirmed catheter-related upper extremity DVT and treated with any standard therapeutic anticoagulation (including LMWH dose reduction to 75% after the first month) for at least 3 months.
✓. Able and willing to provide informed consent.

Exclusion criteria

✕. Active bleeding or other reasons for which anticoagulation is contraindicated.
✕. Other indications requiring ongoing therapeutic dose of anticoagulation as deemed necessary by treating physicians (such as atrial fibrillation, mechanical heart valve, etc.).
✕. Anticoagulation has been permanently stopped or reduced to prophylactic dose prior to enrollment for any reasons, except for participants who were transitioned to apixaban dosing regimen consistent with the protocol (2.5 mg twice daily) for ≤ 3 days .
✕. Known contraindication for apixaban, such as allergy, hypersensitivity, or pregnancy.
✕. Concomitant use of strong inhibitors or inducers of both cytochrome P450 3A4 (enzyme) and P-glycoprotein.

What they're measuring

Venous Thromboembolism (VTE) Rate

Timeframe: 6 months

Trial details

NCT IDNCT06603870

SponsorOttawa Hospital Research Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-10

Contact for this trial

Tzu-Fei Wang, MD, MPH

6137379988 tzwang@toh.ca

View on ClinicalTrials.gov More Venous Thromboembolism trials