Cardiovascular Disease Progression in Survivors of Community Acquired Pneumonia and Lung Infectio… (NCT06601998) | Clinical Trial Compass
RecruitingNot Applicable
Cardiovascular Disease Progression in Survivors of Community Acquired Pneumonia and Lung Infection by Covid-19.
Greece650 participantsStarted 2024-11-08
Plain-language summary
Pneumonia, which can be acquired in the community (including influenza and COVID-19), is a leading cause of mortality. The risk of severe cardiovascular diseases events (stroke, myocardial infarction, pulmonary embolism) increases after infections, but causal mechanisms are not understood yet. There is an essential need for improved understanding of the relationship between pneumonia and cardiovascular diseases and early identification of patients at risk of cardiovascular events to develop tailored therapies.
The overall concept underpinning "Homi-lung" is to investigate the time course of host-microbiome interactions during \& after pneumonia to i) understand the causal relationship between trained immunity, microbiome dysbiosis and cardiovascular and respiratory diseases (CVRD) progressions, ii) define endotypes of pneumonia associated with response to treatment \& CVRD history; iii) develop biomarkers to predict the individual response to the treatment \& CVRD progression, and iv) preclinically validate therapeutical approaches for CVRD during \& after pneumonia.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Adults (18 years or more) of both genders (Female/Male: 50/50 ratio)
✓. No history of severe pneumonia (sCAP, COVID-19 or HAP)
✓. Presence of no or one of the following comorbidities: obesity (defined as body mass index over 35 kg/m2), type 2 diabetes mellitus, hypercholesterolemia, essential arterial hypertension, or familial history of CVD.
✓. Adults (18 years or more) of both genders (Female/Male ratio: 50/50)
✓. No history of severe pneumonia (sCAP, COVID-19 or HAP)
✓. At least two of the following comorbidities: obesity (defined as body mass index over 35 kg/m2), type 2 diabetes mellitus, hypercholesterolemia, essential arterial hypertension, or familial history of CVD
✓. Adults (18 years or more) of both genders (Female/Male ratio: 50/50)
✓. Survivors from severe COVID-19 pneumonia at hospital discharge; all patients had consolidation in chest X-ray or chest computed tomography during acute infection and were treated for pneumonia
Exclusion criteria
What they're measuring
1
The first primary outcome is the rates of major cardiovascular disease event at 6 months.
Timeframe: From enrollment to Month 6.
2
The second primary endpoint is poor cardiorespiratory fitness at 36 months.