CompletedPhase 2

Efficacy of Locally Delivered Rosemary Extract Gel in Management of Periodontitis

Egypt48 participantsStarted 2024-10-20

Plain-language summary

Rosemary extract is known for its antibacterial, anti-inflammatory and anti-oxidant properties that make it a promising therapeutic aid as a local delivery drug in deep periodontal pockets in adjunct to non-surgical periodontal therapy in management of periodontitis. These properties are due to the high content of phenolic compounds such as carnosic acid, urolic acid, rosmarinic acid or chlorogenic acid. Rosemary extract was previously investigated and proved its effectiveness against periodontopathogens in-vitro. Thus, its selected for this study to be administered in a gel form to assess its efficacy in management of periodontitis.

Who can participate

Age range25 Years – 45 Years

SexALL

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Inclusion criteria

✓. Both genders aged between 25-45 years.
✓. Healthy adult patients as evidenced by Burket's oral medicine health history questionnaire.
✓. Stage III grade B periodontitis with at least two non-adjacent sites in posterior teeth with PD ≥ 6 mm, CAL ≥ 5 mm showing BOP and ≤ 4 teeth lost due to periodontitis.
✓. Patients ready to comply with oral hygiene measures.

Exclusion criteria

✕. Smokers.
✕. Pregnant or lactating females.
✕. Drug abusers.
✕. Patients taking antibiotics or performed any periodontal treatment in the previous 6 months.
✕. Patients who have a known allergy or hypersensitivity to rosemary, its constituents, or other members of the Lamiaceae family.
✕. Patients with parafunctional habits.

What they're measuring

probing depth

Timeframe: change from baseline at 3 months

Trial details

NCT IDNCT06601608

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-02

View on ClinicalTrials.gov More Periodontitis (Stage 3) trials