Impact of Indigo Carmine Pump Spraying on the Adenoma Detection Rate

Inclusion Criteria: * Patients with a history of colorectal cancer or colorectal adenoma * Patients whose first-degree relatives have a history of colorectal cancer or colorectal adenoma * Patients with gastrointestinal symptoms (abdominal pain, bloody stool, chronic diarrhea or constipation, Unexplained anemia or weight loss; * Patients with positive fecal occult blood tests Exclusion Criteria: * Patients with severe comorbidity * Patients who are not suitable for colonoscopy * Patients who received urgent or therapeutic colonoscopy * Patients with pregnancy, inflammatory bowel disease, polyposis syndromes, suspected CRC; intestinal obstruction, coagulopathy * Patients with aspirin, clopidogrel or other anticoagulants/ antiplatelet drugs intake within 7 days * Patients with failed cecal intubation * Patients with inadequate bowel preparation quality (Boston score ≤5) * Patients who refuse to participate or to provide informed consent