Oral Cryotherapy Applied to Patients Undergoing Chemotherapy

Inclusion Criteria: * Those receiving treatment in an outpatient chemotherapy unit, * Able to communicate verbally, * Literate, * Eastern Cooperative Oncology Group (ECOG) Performance Score of two or below, * Knowing their diagnosis, * Taking five chemotherapeutic agents that cause taste changes, either alone or in combination (cisplatin, docetaxel, paclitaxel, oxaliplatin, vincristine), * Verbally stating that they experience taste changes, * Not smoking or quitting alcohol, * Not using statins, hypothyroidism, antidiabetic, antipsychotic, hyperthyroidism, antidepressant, antihistamine, anti-inflammatory, antibiotic and antifungal drugs, * Not having Chronic Renal Failure (CKD), metabolic (diabetes, thyroid disease, etc.) and liver (hepatitis, cirrhosis) diseases, * Individuals who volunteered to participate in the study were included in the study. Exclusion Criteria: * Patients who have had their treatment postponed at least twice in a row, * Those with a World Health Organization Oral Toxicity Scale score of 1 and above, * Those who have received radiotherapy to the head and neck region, * Those with head/neck, stomach and liver cancer, * Those who cannot be reached during phone calls, * Those whose chemotherapy protocol has changed or who will be applied to a protocol other than the specified agents, * Those with neutropenia (neutrophils; 1000 mcL and below), * Those with tooth sensitivity, * Those who have experienced a change in taste before starting the chemotherapy…