Not Yet RecruitingNot Applicable

Cardiac Radioablation for VT

United States24 participantsStarted 2026-07

Plain-language summary

The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volume definition using Delayed Enhancement Cardiac MRI (DE-CMR) .

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participants must be 18 years or older. * Automatic implanted cardiac defibrillator present. * VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm. * Ejection fraction ≥20%. * At least one previous cardiac ablation for VT. * VT refractory despite antiarrhythmic medications. * Likely to live for 12 months in the absence of VT. * AICD in a position in the chest RT to be given without direct radiation. * Woman of reproductive age must ensure that she won't become pregnant or breastfeed at the time of RT. * The participant has no contraindications to a Cardiac MRI as per routine Cardiology practice. Exclusion Criteria: * Class IV heart failure * Abandoned leads. * Prior radiation therapy to the chest or upper abdomen. * Interstitial lung disease.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in number of ventricular tachycardia (VT) episodes from pre-cardiac radioablation to post-cardiac radioablation

Timeframe: 56 days pre-treatment and 98 days post treatment (42 day blanking period plus 56 days)

Dose limiting toxicity

Timeframe: 14 weeks

Trial details

NCT IDNCT06593418

SponsorCorewell Health East

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-01

Contact for this trial

John Roberston, MD

248-551-7038 john.robertson@corewellhealth.org

View on ClinicalTrials.gov More Ventricular Tachycardia trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.