CompletedNot Applicable

Nitrate Mouth Rinse and the Oral Microbiome

Canada21 participantsStarted 2024-08-14

Plain-language summary

The study is aimed to determine if changes to the oral microbiome occur after the use of a nitrate rich mouth rinse. Participants with be asked to use either a controlled (water) mouthrinse once daily for 2 weeks while maintaining normal oral hygiene practices, or use the nitrate rich mouthrinse once daily for 2 weeks. Primary Outcome measures: -changes in the composition of the oral microbiome Secondary Outcome measures * Blood Pressure * Salivary Nitric Oxide Levels

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * You are between the ages of 18 and 40. Have no uncontrolled systemic diseases. Participants with mild chronic conditions such as: * Asthma * Type 1 Diabetes Mellitus Exclusion Criteria: * You are under the age of 18. * You have uncontrolled systemic diseases, or acute infections. * You are taking prescription, antibiotics, probiotics, or antimicrobial mouthrinses. * You have a documented true allergy (i.e Hives, Swelling of lips/throat) Soy, Nuts, Seeds, Dairy, Egg products, Fish/Shellfish or Wheat. * The presence of acute or chronic oral conditions including: * Herpes Simplex Virus (recent cold sores) * Stomatitis * Oral Lichen Planus * Angular Cheilitis * Candidiasis * Necrotizing Gingival Diseases * Other inflammatory or infectious pathologies * Active dental caries "cavities" * Any other periodontal diagnosis other than 'Healthy Periodontium' or localized gingivitis

What they're measuring

Microbial composition

Timeframe: 2 weeks

Trial details

NCT IDNCT06588049

SponsorDalhousie University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-16

View on ClinicalTrials.gov More Nitric Oxide trials