* The aim of this study is comparative between: 1. Intra-radicular cryotherapy using cold anti-inflammatory {ketorolac tromethamine at 2-5C}. 2. Intra-radicular final flush anti-inflammatory {ketorolac tromethamine at room temperature}. * In terms of: C. Level of post-operative pain {POP} using a visual analog scale {VAS}. D. Level of substance P in periapical fluid will be analyzed by enzyme-linked immunosorbent assay (ELISA) kit. Outcomes : * Primary outcomes: Level of Post-operative pain. * Secondary outcomes: Level of substance P expression
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Level of pre-operative pain.
Timeframe: before start the operative
Level of Post-operative pain.
Timeframe: 6 hours post operative
Level of Post-operative pain.
Timeframe: 24 hours post operative
Level of Post-operative pain.
Timeframe: 48 hours post operative
Level of Post-operative pain.
Timeframe: 72 hours post operative