CompletedNot Applicable

Multicenter Comparison of Thermal Ablation Versus Thyroid Lobectomy for Subcapsular Papillary Thyroid Microcarcinoma

China2,000 participantsStarted 2019-01-01

Plain-language summary

To compare the clinical outcomes of Thermal ablation with those of thyroid lobectomy in patients with subcapsular papillary thyroid microcarcinoma.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. a unifocal papillary thyroid carcinoma (PTC) diagnosed by fine-needle aspiration or core-needle biopsy;
✓. tumor with a maximum diameter of ≤ 10 mm detected on ultrasound;
✓. tumor located within ≤ 2mm from the thyroid capsule (with or without tumor-associated capsular bulging or capsular discontinuity);
✓. absence of clinical or imaging evidence of gross ETE (involvement of strap muscles, obtuse angles between the tumor and trachea/esophagus, protrusion into the tracheoesophageal groove, and invasion into other neck structures);
✓. no clinical or imaging evidence suggesting lymph node metastasis or distant metastasis

Exclusion criteria

✕. aggressive subtypes of PTC (aggressive subtypes of PTC includes the tall cell, columnar cell, solid, and hobnail variants);
✕. multifocal PTMC;
✕. history of neck surgery or TA;
✕. a follow-up period of \< 24 months;
✕. incomplete follow-up data, or poor-quality pre-treatment ultrasound images

What they're measuring

Progression-free survival

Timeframe: From date of enrollment of the first patient until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 120 months

Trial details

NCT IDNCT06583057

SponsorChinese PLA General Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-07-01

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