The purpose of this study is to learn about the interactions of markers of type 2 diabetes (T2DM) and periodontitis (PD). Study VPE00001 is a multi-center cross-sectional study. Participants will be categorized based on point-of-care hemoglobin A1c (HbA1c) and periodontal disease (PD) staging into 9 subgroups. The key objectives of the study are: * To evaluate immune signatures in well-characterized populations with or without PD and/or T2DM * To evaluate baseline clinical biomarkers of T2DM and PD in well-characterized populations * To evaluate the influence of clinical, immunological, and microbiological biomarkers on the bidirectional relationship between T2DM and PD
Age range
30 Years – 70 Years
Sex
ALL
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Serum titers of total anti-Porphyromonas gingivalis (Pg) antibody (Ab)
Timeframe: Day 01
Serum protease activity inhibition (PAI) titers
Timeframe: Day 01
Serum hemagglutination inhibition (HAI) titers
Timeframe: Day 01
Quantitative deoxyribonucleic acid (DNA)-based detection of Pg (saliva)
Timeframe: Day 01
DNA-based detection of Pg (sub-gingival plaque)
Timeframe: Day 01
Active-matrix metalloproteinase-8 (aMMP-8) levels measured by immunoassay in saliva (chairside assay)
Timeframe: Day 01