The purpose of this study is to learn about the interactions of markers of type 2 diabetes (T2DM) and periodontitis (PD). Study VPE00001 is a multi-center cross-sectional study. Participants will be categorized based on point-of-care hemoglobin A1c (HbA1c) and periodontal disease (PD) staging into 9 subgroups. The key objectives of the study are: * To evaluate immune signatures in well-characterized populations with or without PD and/or T2DM * To evaluate baseline clinical biomarkers of T2DM and PD in well-characterized populations * To evaluate the influence of clinical, immunological, and microbiological biomarkers on the bidirectional relationship between T2DM and PD
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Serum titers of total anti-Porphyromonas gingivalis (Pg) antibody (Ab)
Timeframe: Day 01
Serum protease activity inhibition (PAI) titers
Timeframe: Day 01
Serum hemagglutination inhibition (HAI) titers
Timeframe: Day 01
Quantitative deoxyribonucleic acid (DNA)-based detection of Pg (saliva)
Timeframe: Day 01
DNA-based detection of Pg (sub-gingival plaque)
Timeframe: Day 01
Active-matrix metalloproteinase-8 (aMMP-8) levels measured by immunoassay in saliva (chairside assay)
Timeframe: Day 01