TerminatedPhase 4

Local Methotrexate Injections for the Treatment of Nail Psoriasis

Stopped: The study was terminated due to slow accrual.

United States1 participantsStarted 2025-09-10

Plain-language summary

The investigators hope to learn the efficacy of methotrexate injections for treatment of nail psoriasis.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Subject must be at least 18 years of age * Subject must have nail psoriasis that is clinically diagnosed in at least 3 fingernails Exclusion Criteria: * Subject with any clinically significant condition or situation, other than the condition being studied that, in the opinion of the investigator, would interfere with study evaluations or optimal participation in the study. This is including, but not limited to: immunodeficiency, onychomycosis, any other nail condition other than psoriasis, allergy to methotrexate, triamcinolone acetonide, local anesthetic, normal saline, or any other material used for procedures * Subject who has received radiation therapy, chemotherapy, and/or immunosuppressive drugs within 6 months of study, and/or oral corticosteroids or IV methotrexate for \>1 month within the 6 months of study (exception inhaled steroids); * Subjects who use substances (medications, supplements, ect) known to significantly interact with drugs used as intervention in the study * Subject who is pregnant, breastfeeding, or planning to get pregnant * Subject known to have received treatment with investigational drugs or devices within 30 days prior to enrollment into this study * Subject who is on systemic treatment for psoriasis * Subject with baseline abnormalities in liver function tests or complete blood count * Subjects with diagnosis of renal insufficiency or impairment * Subject who is unwilling to abstain from any cosmetic nail treatments out…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change from baseline of nail dystrophy as measured by the Nail Psoriasis Severity Index

Timeframe: Baseline (week 0), during intervention (weeks 1, 7, 13), post-intervention (weeks 17, 37)

Change from baseline of nail dystrophy as measured by the Physician-Assessed Global Improvement

Timeframe: Baseline (week 0), during intervention (weeks 1, 7, 13), post-intervention (weeks 17, 37)

Trial details

NCT IDNCT06578728

SponsorWeill Medical College of Cornell University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-05

View on ClinicalTrials.gov More Nail Psoriasis trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change from baseline of nail dystrophy as measured by the Nail Psoriasis Severity Index

Timeframe: Baseline (week 0), during intervention (weeks 1, 7, 13), post-intervention (weeks 17, 37)

Change from baseline of nail dystrophy as measured by the Physician-Assessed Global Improvement

Timeframe: Baseline (week 0), during intervention (weeks 1, 7, 13), post-intervention (weeks 17, 37)