A Study of RAY1225 at Different Injection Sites in Participants With Different Body Sizes (NCT06577428) | Clinical Trial Compass
CompletedPhase 1
A Study of RAY1225 at Different Injection Sites in Participants With Different Body Sizes
China48 participantsStarted 2024-07-30
Plain-language summary
The purpose of this study is to compare the amount of RAY1225 that gets into the blood stream and how long it takes the body to get rid of it, when injected under the skin of the upper arm and thigh compared to the abdomen. The study will be conducted in healthy males and females with different body sizes. The tolerability of RAY1225 will be evaluated and information about any side effects experienced will be collected. For each participant, the study will last about 7 weeks, including screening.
Who can participate
Age range18 Years – 50 Years
SexALL
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Inclusion criteria
✓. Body mass index (BMI) ≥19 kg/m2 and total body weight \>50 kg for male, \>45 kg for female at Screening (calculated as a function of measured height and weight according to the formula, BMI = kg / m2 where m2 is height in meters squared);
✓. Ability to understand and willingness to sign a written informed consent form;
✓. Normal physical examination, vital signs, 12-lead ECG, and clinical laboratory values, or any abnormality that is non-clinically significant.
Exclusion criteria
✕. Participants with an allergic disposition (multiple drug and food allergies) or who, as determined by the investigator, are likely to be allergic to the investigational drug product or any component of the investigational drug product;
✕. Participants had taken prescription, over-the-counter, herbal, or vitamin products within 14 days prior to screening；
✕. Smoking more than 5 cigarettes per day within 3 months prior to screening，or who cannot stop using any tobacco products during the study period;
✕. Participants who donated blood/bleeding profusely (\> 400 mL) 3 months prior to randomization;
✕. Those with clinically significant Electrocardiogram(ECG) abnormalities, or QTcF \> 450ms;
✕. Participants who test positive at screening for human immunodeficiency virus (HIV), Hepatitis B surface antigen (HBsAg), Hepatitis C virus (HCV) antibody or Syphilis spirochete-specific antibodies (TPPA);
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What they're measuring
1
Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve of RAY1225 From Time Zero to Infinity (AUC[0-∞])