Mechanisms Underlying Hypoxic, Heat and Cross-tolerance Adaptation in Women (NCT06575985) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Mechanisms Underlying Hypoxic, Heat and Cross-tolerance Adaptation in Women
Slovenia30 participantsStarted 2024-10
Plain-language summary
This study will consist of a parallel-groups design, with 30 healthy active female participants randomly assigned to either an experimental heat acclimation and exercise intervention, or a thermo-neutral exercise intervention control group. Interventions will be 10 days in duration, and consist of daily 60-minute exercise bouts under the appropriate environmental condition. Before and after each intervention, various tests will be conducted to establish exercise capacity under various environmental conditions, as well as underlying mechanisms of physiological adaptation induced by each intervention.
Who can participate
Age range
18 Years – 35 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age: 18 - 35 years
* Body mass index: 18.5 - 25.0 kg/m\^2
* Regular physical activity (at least 30 minutes of moderate-intensity activity, three times per week)
Exclusion Criteria:
* Habitual smoker within the past 5 years
* History of metabolic disorders or any medications deemed to pose an undue risk or introduce bias in any outcome measures
* Exposure to altitude \> 2000 m above sea level within four weeks of scheduled participation
* Permanent residence at altitude \> 1000 m above sea level
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Exercise capacity under thermo-neutral normoxic conditions
Timeframe: Measured once before (pre) and once up to 1 week after (post) the intervention period
2
Exercise capacity under hot normoxic conditions
Timeframe: Measured once before (pre) and once up to 1 week after (post) the intervention period
3
Exercise capacity under thermo-neutral hypoxic conditions
Timeframe: Measured once before (pre) and once up to 1 week after (post) the intervention period