Use of Total-Body PET to Quantify Systemic and Cutaneous Inflammation in Psoriasis Patients Before and After Intervention With a Nutritionally Balanced Diet

Inclusion Criteria: * Adults (\>18 year) * Both sexes * Must have a history of psoriasis of at least 3% body surface area affected by skin psoriasis (in a body area that the subject will allow the PI to perform several skin biopsies as noted below (optional)) and may carry a diagnosis of psoriatic arthritis as well * Patients will have a BMI of \>/=25 which is consistent with being overweight - Willing and able to fast for at least 6 hours before and for the duration of the scan visit * No strenuous exercise for 24 hours prior to being scanned * Recruited patients must habitually consume a WD-type diet that will be evaluated by using DHQ III food frequency questionnaire along with three-day food record14. Subsequently, the Healthy Eating Index will be calculated and participants with a poor dietary pattern (score below 58) will be eligible for the study15. Exclusion Criteria: * Those taking anti-diabetic oral or injected medications * Those already ingesting a caloric- or component-restricted diet * Vegan, vegetarian or food allergy or intolerance to the ingredients of the diet * \>5% change in body weight in the last 2 months * Those taking systemic medications for the purpose of treating psoriasis or psoriatic arthritis for at least 3 months prior to first PET scan or during the duration of the trial * Self-reported history of dysphoria or anxiety in closed spaces (claustrophobia) * Uncontrolled diabetes or blood glucose level greater than 180 mg/dl at the time of radiot…