Active — Not RecruitingPhase 1/2

Effect of Intraarticular Injection of Tenoxicam and Hyaluronic Acid Versus Platelet-Rich Plasma and Hyaluronic Acid in Temporomandibular Joint Internal Derangement

Egypt60 participantsStarted 2024-02-20

Plain-language summary

To compare the effect of intraarticular injection of Tenoxicam and Hyaluronic acid Versus Platelet-rich plasma and Hyaluronic acid in the management of patients with TMJ internal derangement with reduction.

Who can participate

Age range18 Years – 45 Years

SexALL

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Inclusion criteria

✓. Patients age must be (18 -45).
✓. Patients have painful joint, clicking sound, with or without limited mouth opening.
✓. patients are unresponsive to conservative treatment.
✓. Patient's ability and desire to complete the treatment protocol and follow-up visits.
✓. Patients with internal derangement with reduction confirmed by MRI imaging.

Exclusion criteria

✕. Patient with an inflammatory or connective tissue disease
✕. Patient with previous invasive TMJ surgical procedure.
✕. Neurologic disorders
✕. History of injection of any substance into the target TMJ during previous 6 months.
✕. History of drug allergy.
✕. Patient with a history of bony or fibrous adhesion.
✕. Malignant disease in the head and neck region.
✕. TMJ Internal derangement without reduction.

What they're measuring

Intracapsular Pain and pain during movement

Timeframe: at 1 week, 4, 12, and 24 weeks

Clicking sound

Timeframe: at 1 week, 4, 12, and 24 weeks

Maximum inter-incisal opening (MIO)

Timeframe: at 1 week, 4, 12, and 24 weeks

Trial details

NCT IDNCT06572904

SponsorMansoura University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-10-20

View on ClinicalTrials.gov More Temporomandibular Joint Internal Derangement trials