Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals (NCT06569329) | Clinical Trial Compass
RecruitingNot Applicable
Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
United States90 participantsStarted 2024-08-20
Plain-language summary
The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.
Who can participate
Age range
18 Years – 95 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis of pulp necrosis with apical periodontitis (AP) confirmed by pulp tests, clinical and radiographic evidence.
* Tooth with no response to cold and electric pulp testing (done at screening).
* Single canalled premolars with intact pulp chamber walls.
* Patient must be 18 years of age or older
Exclusion Criteria:
* Teeth with vital pulp.
* Teeth with incomplete root formation (immature with apical periodontitis).
* Teeth with extensive crown destruction.
* Teeth with previous endodontic treatment or intervention (pulp debridement).
* Teeth with acute/ chronic apical abscess.
* Teeth with internal or external resorption.
* Teeth with non-odontogenic facial pain.
* Teeth with periodontal pockets deeper than 4 mm.
* Teeth with advanced untreated periodontal disease or recent periodontal surgery.
* Teeth with mobility score greater than 2.
* Teeth with a fracture or visible crack.
* Patients with diabetes or immune compromised conditions.
* Patients who received systemic antibiotics within the last 3 months.
* Patients taking corticosteroids.
* Patients who are pregnant.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Assessment of the changes in the bacterial count at various time points during the root canal procedure.
Timeframe: Baseline (pre-intervention) and during the intervention and immediately after the intervention