Endoscopic Gastroenterostomy Versus Surgical Gastrojejunostomy (NCT06567691) | Clinical Trial Compass
By InvitationNot Applicable
Endoscopic Gastroenterostomy Versus Surgical Gastrojejunostomy
United States34 participantsStarted 2025-08-01
Plain-language summary
Recent comparative data suggest that EUS gastroenterostomy offers more durable patency than enteral stents for treatment of malignant GOO, leading some endoscopists to suggest that EUS gastroenterostomy should be the preferred endoscopic treatment approach.
EUS gastroenterostomy and surgical gastrojejunostomy have been compared in retrospective cohort analysis, suggesting a high technical success rate a shorter hospital length of stay for the endoscopic approach \[4\]. Comparison of these techniques has not been reported in controlled prospective fashion. A prospective trial is necessary in order to define the optimal interventional management option for treatment of malignant GOO in the context of the contemporary and rapidly evolved range of available endoscopic and surgical treatment options.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years or older
* Able to provide informed consent
* Biopsy-proven cancer
* Cancer without surgical resection as a curative treatment option
* Clinical and radiographic presentation consistent with primary or metastatic tumor causing foregut obstruction at the level of the pylorus and/or duodenum
Exclusion Criteria:
* Age \<18 years
* Pregnancy
* Unable to provide informed consent
* White Blood Count \< 3,000
* Absolute Neutrophil Count \< 1,500
* International normalized ratio \> 1.6
* Platelet count \< 100,000
* Cancer with surgical resection as a curative treatment option
* Surgically altered foregut anatomy
* Multifocal intestinal obstruction
* Abdominal ascites prohibitive of surgical candidacy
* Abdominal wall mesh prohibitive of surgical candidacy
* Child's Class B or C cirrhosis
* Gastroesophageal varices or known portal hypertension
* Body mass index \>40
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Compare of restoration of oral intake following EUS versus surgical gastrojejunostomy