Preliminary Evaluation of the Safety and Tolerability of SPOT-mRNA01 Subcutaneously Administered in Healthy Subjects

Exclusion criteria

• ✕. Any transient or chronic skin condition, disorder, or infection within 20 cm of the target areas before treatment that, in the opinion of the investigator, may confound study results.
• ✕. History of laser treatment or chemical peels or any cosmetic anti-aging treatments to the target areas within six months of the study treatment.
• ✕. History of surgical procedures to target areas, including removal of benign or malignant skin cancers that, in the opinion of the investigator, may confound study results.
• ✕. Participant with a history of heavy smoking, alcohol or drug abuse or steroid treatment.
• ✕. Pregnant or breast-feeding females.
• ✕. History of anaphylaxis or allergic reactions to any constituent of the study product and/or local anesthetics, and/or history of severe abnormal drug reaction.
• ✕. Those who have participated in clinical trials of other investigational drugs within 3 months before the study treatment.
• ✕. Those who are not suitable for subcutaneous injection and biopsy.