CompletedPhase 3

Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia

Bangladesh50 participantsStarted 2022-07-01

Plain-language summary

The goal of this clinical trial is to learn if drug clomiphene citrate improves sperm parameters in infertile men with idiopathic oligoasthenozoospermia. It will also learn about the safety of clomiphene citrate. The main questions it aims to answer are: * Does drug clomiphene citrate change sperm count and motility in infertile men with idiopathic oligoasthenozoospermia? * What medical problems do participants have when taking drug clomiphene citrate? Researchers will compare drug clomiphene citrate to a placebo (a look-alike substance that contains no drug) to see if drug clomiphene citrate works to treat idiopathic oligoasthenozoospermia.

Who can participate

Age range25 Years – 45 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Infertile men * Idiopathic oligoasthenozoospermia (serum FSH and serum LH range was 2-7 IU/mL and serum testosterone level was \>300 ng/dl) Exclusion Criteria: * Azoospermia * Body mass index \<18 kg/m2 and \>30 kg/m2 * Any abnormality on genital examination and scrotal sonogram * History of genital diseases \& genital surgery * Medical and endocrine disorders like uncontrolled diabetes mellitus, severe kidney disease and liver insufficiency * Psycho-sexual abnormalities * Antioxidant supplements in previous 3 months * Smoking, drug, alcohol or substance abuse * History of chemotherapy or radiotherapy * Presence of any gross female factor abnormality

What they're measuring

Change from baseline in sperm motility at 12 weeks

Timeframe: Baseline and 12 weeks

Change from baseline in sperm count at 12 weeks

Timeframe: Baseline and 12 weeks

Trial details

NCT IDNCT06564961

SponsorShakeela Ishrat

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-06-30