CompletedPhase 3

Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia

Bangladesh50 participantsStarted 2022-07-01

Plain-language summary

The goal of this clinical trial is to learn if drug clomiphene citrate improves sperm parameters in infertile men with idiopathic oligoasthenozoospermia. It will also learn about the safety of clomiphene citrate. The main questions it aims to answer are: * Does drug clomiphene citrate change sperm count and motility in infertile men with idiopathic oligoasthenozoospermia? * What medical problems do participants have when taking drug clomiphene citrate? Researchers will compare drug clomiphene citrate to a placebo (a look-alike substance that contains no drug) to see if drug clomiphene citrate works to treat idiopathic oligoasthenozoospermia.

Who can participate

Age range

25 Years – 45 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Infertile men * Idiopathic oligoasthenozoospermia (serum FSH and serum LH range was 2-7 IU/mL and serum testosterone level was \>300 ng/dl) Exclusion Criteria: * Azoospermia * Body mass index \<18 kg/m2 and \>30 kg/m2 * Any abnormality on genital examination and scrotal sonogram * History of genital diseases \& genital surgery * Medical and endocrine disorders like uncontrolled diabetes mellitus, severe kidney disease and liver insufficiency * Psycho-sexual abnormalities * Antioxidant supplements in previous 3 months * Smoking, drug, alcohol or substance abuse * History of chemotherapy or radiotherapy * Presence of any gross female factor abnormality

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change from baseline in sperm motility at 12 weeks

Timeframe: Baseline and 12 weeks

Change from baseline in sperm count at 12 weeks

Timeframe: Baseline and 12 weeks

Trial details

NCT IDNCT06564961

SponsorShakeela Ishrat

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-06-30

View on ClinicalTrials.gov More Infertility, Male trials