CompletedNot Applicable

Ventilator Settings for Bronchoscopy During Mechanical Ventilation: a Randomized Controlled Study

France46 participantsStarted 2024-09-10

Plain-language summary

Fiberoptic bronchoscopy (FOB) can cause a significant increase in respiratory resistances and airway pressure during mechanical ventilation (MV), which can jeopardize the delivery of the ventilatory assistance. This randomized controlled study tests the hypothesis that new ventilator settings aimed at reducing airway pressure may facilitate FOB during MV. Results of this trial should lead to propose a new ventilatory strategy for critically ill patients needing a FOB procedure under MV.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Age ≥18 years; * Acute respiratory failure requiring invasive mechanical ventilation in the intensive care unit; * Indication of either a fiberoptic bronchoscopy (FOB) procedure or a percutaneous tracheostomy under FOB control; * Patient under sedation with Richmond Agitation and Sedation Scale(RASS) ≤-2, * Written informed consent obtained by the patient or the patient legal representative Exclusion Criteria: * Presence of an absolute contraindication to FOB (respiratory arrest, severe acute respiratory distress syndrome (ARDS), refractory shock, uncontrolled heart rhythm disorder); * Patients in respiratory distress or with severe patient-ventilator desynchronies ; * Patients refusing FOB; * Pregnancy ; * Moribund patients (according to American Society of Anesthesiologists (ASA) Physical status score classification, class 5: high probability of death within 24 hours) or at high risk of death during the FOB procedure; * Patients deprived of liberty; * Patients under curators or guardianship.

What they're measuring

Determine if the use of specific ventilator settings facilitates the performance of fiberoptic bronchoscopy (FOB) during mechanical ventilation compared to conventional ventilator settings.

Timeframe: 5 minutes after bronchoscopy initiation

Trial details

NCT IDNCT06562725

SponsorCentre Hospitalier Arras

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-12