ACL-R Opioid Sparing Study

Inclusion Criteria: * 14-85 years of age. * Patients undergoing primary ACL-R with or without meniscus repair or meniscectomy, with or without chondroplasty. * Patients weigh at least 90lbs at time of enrollment. * Surgery scheduled at a Campbell Clinic Surgery Center (Midtown or Wolf River). * Willing and able to provide written informed consent. * Willing and able to cooperate with postoperative therapy. * Speak and read fluent English. Exclusion Criteria: * Multiligament knee reconstruction. * Pre-injury opioid consumption. * Substance abuse disorder (illicit drug abuse, alcoholism, etc). * Concomitant injuries or surgeries warranting pain medication (i.e. polytrauma patient). * Chronic pain syndrome. * Renal disease. * Currently taking selective serotonin reuptake inhibitors and/or serotonin and norepinephrine reuptake inhibitors. * Known sensitivity, allergy, or intolerance to medications within protocols. * History of diabetes. * Currently taking glucagon-like peptide 1 agonist. * Female patient who is pregnant on day of surgery or becomes pregnant during study period.