IC14 for Treatment of Acute Decompensated Heart Failure

Inclusion criteria

• ✓. Primary diagnosis for hospitalization is decompensated heart failure established as the finding at admission of both conditions listed below:
• ✓. dyspnea or respiratory distress or tachypnea at rest or with minimal exertion; and
• ✓. evidence of elevated cardiac filling pressure or pulmonary congestion (at least one of the conditions must be met):
• ✓. The patient has a prior documentation of impaired left ventricular systolic function (left ventricular ejection fraction \<40%) at most recent assessment by any imaging modality (within 12 months).
• ✓. The patient is symptomatic for moderate to severe dyspnea at time of enrollment as indicated by a score on the visual analog scale for dyspnea of 40 or more (in a scale of 1 to 100, where 0 is no shortness of breath and 100 is extremely short of breath) in the prior 12 hours.
• ✓. The patient has recently received (past 24 hours) or is scheduled to received intravenous loop diuretics.
• ✓. The patient is of age ≥21 years old, willing and able to provide written informed consent and to comply with the protocol (i.e., reporting of symptoms).
• ✓. The patient has screening plasma C-reactive protein levels \>3 mg/L (0.3 mg/dL).

Exclusion criteria