Not Yet RecruitingNot Applicable

Surgical and Pharmacological Efficacy of Knosp Grade 0-2 Prolactinoma

600 participantsStarted 2024-10-01

Plain-language summary

The investigators carried out a multi-center comparative study, involving hospitals including the Second Affiliated Hospital of Zhejiang University School of Medicine, Peking Union Medical College Hospital, West China Hospital, Wenzhou First Hospital, and Li Huili Hospital. This study aimed to compare the efficacy of medication and surgery for specific subtypes of microadenomas and clearly defined macroadenomas (Knosp grades 0-2), in order to determine which is more effective and which has fewer benefits, thereby enhancing the evidence base.

Who can participate

Age range20 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Prolactin level greater than three times the normal upper limit * MRI indicates Knosp Grade 0-2 pituitary adenoma Exclusion Criteria: * MRI indicates Knosp grade 3-4 pituitary adenoma * Taking antidepressants or other psychotropic drugs * Patients allergic to bromocriptine or cannot tolerate surgery * Women defined as surgical infertility (i.e. hysterectomy, bilateral salpingectomy, or bilateral oophorectomy), or amenorrhea for more than 2 years * Critical illness patients, such as those with progressive consciousness disorders, cerebral hernias, and other emergency situations

What they're measuring

pituitary hormone levels

Timeframe: At 1, 3, 6, 9 and 12 months postoperatively

pituitary MRI

Timeframe: At 1,6 and 12 months postoperatively

Trial details

NCT IDNCT06556186

SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-03-31

Contact for this trial

Qun Wu, Doctor

+86-13605810393 2192010@zju.edu.cn

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