Not Yet RecruitingNot Applicable

Topo-Pachymetric Customized Accelerated Epi-On Vs Accelerated Epi-Off Corneal Cross Linking in Keratoconus Management

Egypt55 participantsStarted 2024-08-15

Plain-language summary

The objective of this study is to compare the clinical effectiveness and safety of Topo-Pachymetric Customized Accelerated Epithelium-On (aCFXL) to Standard Accelerated Epithelium-Off (aCXL) Corneal Collagen Cross-Linking in the management of keratoconus. The study aims to evaluate visual and structural outcomes, to provide valuable insights into optimizing treatment strategies.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age: 18 years or older
✓. Corrected distance visual acuity (CDVA) of ≥ 0.3 Snellen.
✓. Central corneal thickness (de-epithelialized) of ≥ 400 micron.
✓. Corneal endothelial count of ≥ 2000.

Exclusion criteria

✕. Previous eye surgery
✕. The presence of lesions other than keratoconus, central or paracentral scaring
✕. History of Cross linking
✕. History of viral keratitis
✕. Connective tissue diseases
✕. Pregnancy or lactation during the study.
✕. The presence of nystagmus

What they're measuring

Amount of corneal flattening

Timeframe: 6 months

Change in the endothelial cell count.

Timeframe: 6 months

Trial details

NCT IDNCT06549387

SponsorKasr El Aini Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-28

View on ClinicalTrials.gov More Amount of Corneal Flattening (Kmax Flattening) trials