Clinicopathological Features and Genetic Susceptibility Screening of Recurrent Drug-induced Liver Injury

Inclusion criteria

• ✓. Liver enzymes returns to normal or has a tendency to remission after the first drug liver injury;
• ✓. Signs and symptoms of liver injury after the patient takes the different drugs for liver injury again, and the liver enzymes returns to normal through follow-up.
• ✓. RUCAM ≥6 and met one of the following biochemical conditions: (1)ALT≥5 ULN, (2) or ALP ≥2 ULN, (3) or ALT≥3 ULN and TBil≥2 ULN.
• ✓. RUCAM between 3-5, five experienced hepatologists in leading site evaluate and vote the diagnosis of DILI, the case would be enrolled if only ≥4 out of 5 hepatologists agree with the diagnosis.
• ✓. Onset to enrollment ≤3 months.