This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old. In the study group, patients will receive melatonin supplementation for at least two months prior to their IVF cycles. Cumulus cells will be collected after oocyte retrieval, and IVF outcomes will be assessed.
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Live birth rate (%)
Timeframe: through study completion, an average of 4 year
oxygen consumption rate of mitochodria (%)
Timeframe: through study completion, an average of 4 year
mRNA levels of cumulus cell genes
Timeframe: through study completion, an average of 4 year