RecruitingNot Applicable

National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry

Brazil1,211 participantsStarted 2025-04-30

Plain-language summary

The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data. The main questions it aims to answer are: Which genes are most commonly affected? What is the frequency of these genetic alterations in our population? Participants will be interviewed in routine medical care visits and their DNA will be sequenced.

Who can participate

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines * Agree to receive genetic counseling * Sign informed consent form * Provide the information required in the case report form Exclusion Criteria: * Signature absent from informed consent form * Inadequate buccal swab (sample may be collected twice)

What they're measuring

Diagnostic yield

Timeframe: 30 months after study start date

Genetic diversity

Timeframe: 30 months after study start date

Variant frequency

Timeframe: 30 months after study start date

Trial details

NCT IDNCT06546137

SponsorHospital do Coracao

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-08-31

Contact for this trial

Adriana Bastos Carvalho, MD PhD

+552130372105 carvalhoab@biof.ufrj.br

View on ClinicalTrials.gov More Cardiomyopathy, Hypertrophic trials