CompletedNot Applicable

Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension

United States19 participantsStarted 2024-09-04

Plain-language summary

The purpose of the study is to learn more about how low-resistance training impacts frailty and the quality of life of people with pulmonary arterial hypertension (PAH). Low-resistance training is an evidence-based approach that may help patients improve their functional ability.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of PAH: idiopathic, heritable, associated with connective tissue disease, congenital heart disease, human immunodeficiency virus, drug- or toxin, or portopulmonary hypertension * On stable PAH therapy for 3 months Exclusion Criteria: * World Health Organization (WHO) functional class IV * Left ventricular ejection fraction \< 40% (via transthoracic echocardiogram (TTE) within one year of screening) * Moderate or severe concomitant lung disease: Chronic Obstructive Pulmonary Disease (COPD) or interstitial lung disease * Enrollment in a clinical trial * Recent hospitalization (within 4 weeks of screening) * Inability to perform the Short Physical Performance Battery or wheelchair bound

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Adverse Events

Timeframe: Between baseline and 12-week follow-up

Feasibility of Recruitment

Timeframe: Through study completion, an average of twice per year

Feasibility of Study

Timeframe: Through study completion, an average of twice per year

Short Performance Physical Battery (SPPB) and emPHasis-10 (E10) scores

Timeframe: Between baseline and 12-week follow-up

Patient/ Caregiver Exit Interview

Timeframe: Upon conclusion of the 12-week follow-up

Trial details

NCT IDNCT06543745

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-31

View on ClinicalTrials.gov More Pulmonary Arterial Hypertension trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Adverse Events

Timeframe: Between baseline and 12-week follow-up

Feasibility of Recruitment

Timeframe: Through study completion, an average of twice per year

Feasibility of Study

Timeframe: Through study completion, an average of twice per year

Short Performance Physical Battery (SPPB) and emPHasis-10 (E10) scores

Timeframe: Between baseline and 12-week follow-up

Patient/ Caregiver Exit Interview

Timeframe: Upon conclusion of the 12-week follow-up