Molecular Optimization Via Exercise (MOVE)

Exclusion criteria

• ✕. Subject requires assistance with any activity of daily living, excluding continence.
• ✕. Subject lives in an institutional setting (skilled nursing facility or residential care facility for the elderly).
• ✕. Abnormal bleeding or coagulopathy (self-report): History of a bleeding disorder, wound healing disorder or clotting abnormality.
• ✕. Female participants must be post-menopause.
• ✕. Musculoskeletal conditions that would prevent completion of any required exercise testing.
• ✕. Elevated blood pressure readings (screening test): Resting Systolic Blood Pressure (SBP) ≥150 mmHg or resting Diastolic Blood Pressure (DBP) ≥90 mmHg
• ✕. Diabetes (self-report and screening tests): Treatment with any hypoglycemic agents (self-report), fasting glucose \>125 mg/dL (screening test; may reassess once), use of hypoglycemic drugs for non-diabetic reasons (self-report).
• ✕. Pulmonary (self-report): Clinical diagnosis of any chronic pulmonary disease that limits exercise capacity.