CompletedNot Applicable

Periodontal Therapy Effect on the Ratio of TNF-α to IL-10 in Periodontis With/Out DM

Egypt36 participantsStarted 2024-03-01

Plain-language summary

Periodontitis is a chronic inflammatory disease affecting the periodontium, characterized by irreversible damage to the gingiva, periodontal ligament, and alveolar bone. It is prevalent among adults, significantly impacting oral health and quality of life. This study investigates the effect of non-surgical periodontal therapy (NSPT) on the levels of Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-10 (IL-10) in periodontitis patients with and without diabetes mellitus type II.

Who can participate

Age range20 Years – 50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Both genders. Age (20-50 ) years old. Participants willing to commit for the entire period of the trial and agreed to sign the written consent after full explanation of the study. Generalized Periodontitis patients . Having at least 20 tooth excluding wisdoms. Systemically free according to the modified Burkett's health history questionnaire except for diabetes mellitus (Burket, Greenberg and Glick 2003). Exclusion Criteria: * Smokers. * Intake of immunosuppressive drugs, antibiotics or anti-inflammatory drugs throughout the last three months prior to the study . * status of pregnancy or lactation. * allergy to local anesthetic. * Prisoners . * The vulnerable group ; mentally and physically disabled patients .

What they're measuring

detect difference in the ratio of tumor necrosis factor-α interleukin-10 in periodontitis patients with and without diabetes

Timeframe: 8 weeks

Trial details

NCT IDNCT06539039

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-05-01

View on ClinicalTrials.gov More Periodontitis Generalized trials