CompletedNot Applicable

Perioperative Use of Atosiban for Ultrasound-indicated Cerclage to Reduce Spontaneous Preterm Birth(sPTB)

China334 participantsStarted 2018-01-03

Plain-language summary

After ultrasound-indicated cerclage, some pregnant women still experience sPTB, and there is controversy regarding the use of tocolytic agents during the perioperative period to reduce the incidence of sPTB. In this study, the investigators employed a randomized double-blind method to investigate whether the use of atosiban during the perioperative period can reduce the incidence of sPTB before 34 weeks.

Who can participate

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * (i) Viable singleton gestation between 14 0/7 and 23 6/7 weeks of gestation. * (ii) Previous history of miscarriage or preterm labor in mid-pregnancy. * (iii) Transvaginal ultrasound examination showed that the cervix is 25mm or less at gestations less than 24 weeks. Exclusion Criteria: * (i) Women with uterine contractions. * (ii) Vaginal bleeding. * (iii) Symptoms of chorioamnionitis. * (iv) Medically indicated PTB (severe preeclampsia, placental abruption, preterm premature rupture of membranes). * (v) Major structural or chromosomal abnormalities. * (vi) Contraindication to atosiban. * (vii) Had received atosiban or any tocolytic agents within 7 days before their presentation.

What they're measuring

Rate of sPTB

Timeframe: up to 34 weeks

Trial details

NCT IDNCT06537778

SponsorChildren's Hospital of Chongqing Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-02-12

View on ClinicalTrials.gov More Cervical Cerclage trials