Individualized Exercise Combined With Manual Therapy in Severe Hemophilia Patients With Polyarthropathy

Inclusion Criteria: * over 20 years old and diagnosed with severe hemophilia * those who receive prophylaxis regularly * there are more than 2 target joints (hemophilic arthropathy) Exclusion Criteria: * unwilling to sign the informed consent * any neurological disease or specific musculoskeletal condition (such as fracture) one year ago * more than 3 (excluding 3) joint replacement surgeries (different joints) * unable to walk due to hemophilia joint disease or any other diseases * major bleeding events that pose risks or hinder research * unable to follow instructions due to cognitive impairment