Individualized Exercise Combined With Manual Therapy in Severe Hemophilia Patients With Polyarthr… (NCT06535971) | Clinical Trial Compass
CompletedNot Applicable
Individualized Exercise Combined With Manual Therapy in Severe Hemophilia Patients With Polyarthropathy
Taiwan10 participantsStarted 2024-07-05
Plain-language summary
The aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.
Who can participate
Age range
20 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* over 20 years old and diagnosed with severe hemophilia
* those who receive prophylaxis regularly
* there are more than 2 target joints (hemophilic arthropathy)
Exclusion Criteria:
* unwilling to sign the informed consent
* any neurological disease or specific musculoskeletal condition (such as fracture) one year ago
* more than 3 (excluding 3) joint replacement surgeries (different joints)
* unable to walk due to hemophilia joint disease or any other diseases
* major bleeding events that pose risks or hinder research
* unable to follow instructions due to cognitive impairment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Hemophilia Joint Health Score (HJHS)
Timeframe: before intervention (baseline), after intervention 6th week and 12th week
2
Visual Analogue Scale (VAS)
Timeframe: before intervention (baseline), after intervention 6th week and 12th week
3
6 minute walk test
Timeframe: before intervention (baseline), after intervention 6th week and 12th week
4
Hemophilia Activity List (HAL)
Timeframe: before intervention (baseline), after intervention 6th week and 12th week
5
EQ-5D-5L
Timeframe: before intervention (baseline), after intervention 6th week and 12th week