STOP-stroke: STroke Outcome Prediction in the Acute Treatment Setting (NCT06534645) | Clinical Trial Compass
RecruitingNot Applicable
STOP-stroke: STroke Outcome Prediction in the Acute Treatment Setting
Switzerland250 participantsStarted 2024-10-29
Plain-language summary
The STOP-stroke project aims at improving prediction of outcome early after stroke. In order to achieve this, we need to understand reasons (important variables) for prediction in a real clinical prognostication process.
We aim to:
1. Test the predictive performance of stroke neurologists for outcome prediction (NIHSS at 24 hours and 3 months and mRS at 3 months after stroke onset) prospectively and in a real clinical setting, and to explore the most important baseline variables in their prognostication process.
2. Test the prediction performance of our DL models when being provided with structured clinical and/or imaging information from the same patients as the neurologists; and to discover most relevant features of the input data.
3. Use the information gained from our experiments for improving our DL algorithm. This will include an error analysis on the missclassifications of models and neurologists to understand the pitfalls of both approaches. We anticipate to develop a robust, reliable and clinically feasible application ready for testing in a prospective, observational trial.
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients from up to 18 years years of age without any upper age limit.
* Patients with clinical suspicion of acute ischemic stroke (acute onset focal neurological deficit) at the discretion of the paramedic or treating physician within 24 hours of symptom onset including wake-up situation and unclear symptom onset planned for clinically indicated neuroimaging.
* Patients with externally performed neuroimaging before admission or referral to the USZ will be included from the time point N2 on if no refusal of use of data is documented.
Exclusion Criteria:
• Patients with documented objection of subsequent use of personal health data or patients who reject the use of personal health data during follow-up after initial informed consent by an independent physician in the acute setting. We will not include patients in the study if there is no written informed consent either from the patient her-/himself, the next of kin or the independent physician.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.