The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals … (NCT06532851) | Clinical Trial Compass
RecruitingNot Applicable
The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
Jordan54 participantsStarted 2024-01-01
Plain-language summary
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears. 54 participants, aged 35-55, will be randomly assigned to one of three groups: PRE, aerobic exercise, or control (standard of care physical and medical therapy). The study will utilize MRI T2 mapping to assess changes in cartilage composition and patient-reported and performance-based measures to evaluate clinical outcomes. This pilot study will also determine the feasibility and issues related to recruitment and retention for a larger trial.
Who can participate
Age range35 Years – 55 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Are between 35 and 55 years of age.
✓. Have a symptomatic degenerative medial meniscus tear as evidenced by:
✓. Have clearance from their personal physician to participate in an exercise program.
Exclusion criteria
✕. Radiographic evidence of OA (K-L grade 2 or above).
✕. A repairable meniscus injury (longitudinal tear in the outer 1/3 of the meniscus).
✕. A meniscus injury that requires meniscectomy (locked knee).
✕. Prior or current ligament injury or surgery of the involved knee.
✕. Prior or current injury or surgery to contra-lateral knee.
✕. Pathological ligamentous laxity upon examination of the knee
✕. An inflammatory arthritic condition or
What they're measuring
1
Short echo T2*
Timeframe: Baseline, 3-month, 12-month, and 5 years follow-ups.
Trial details
NCT IDNCT06532851
SponsorJordan University of Science and Technology