The Aim of This Study is to Determine the Incidence of Alterations in Fluorescent In Situ Hybridisation (FISH) of Spermatozoa and to Evaluate the Efficacy of the Use of Annexin Columns (MACS®) in Patients With Altered FISH Undergoing In Vitro Fertilisation Techniques

Inclusion Criteria: * Women between 18 and 40 years of age. Men between 18 and 55 years of age. * Couples without any common, previous and healthy children. * Couples with indication of IVF-ICSI cycle with Preimplantation Genetic Test for Aneuploidy (PGT-A). * Men with altered sperm FISH results. Exclusion Criteria: * Prior voluntary sterilization. * Existence of documented medical contraindication for infertility treatment. * Existence of documented medical contraindication to pregnancy. * Existence of a documented medical situation that seriously interferes with the development of the offspring. * Impossibility to comply with the treatment for health-related reasons or other family or social environment-related reasons. * Existence of a documented situation referring to any other circumstance that may seriously interfere with the development of the offspring submitted for consideration to a health care ethics committee or similar body. * One or both partners with positive serology for HIV, HBV and VDRL. * One or both partners with partner with altered karyotype.