Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma

Inclusion Criteria: * willing to participate in the study and sign the informed consent * age ≥18 years old * researchers evaluated that it was suitable to participate in this translational study * Endometrial cancer was confirmed histologically * histopathological molecular classification was consistent with pMMR type and POLE wild type * The tumor tissue obtained by operation was the primary lesion Exclusion Criteria: * Received chemotherapy within 14 days prior to sample collection, or received anti-tumor drug therapy such as radiotherapy, biotherapy, endocrine therapy, targeted therapy, immunotherapy, within 21 days prior to sample collection * previously treated with KIF18A inhibitors * researchers believed that the subjects were not suitable for the translational study for other reasons