CompletedPhase 3

Efficacy of Bupivacaine-magnesium Combination Versus Bupivacaine Alone in Genicular Nerve Block

Egypt94 participantsStarted 2024-08-01

Plain-language summary

It is proved that the addition of magnesium sulfate to local anesthetics for neuraxial anesthesia improves the quality of analgesia and prolongs the duration of anesthesia . In-vitro and in-vivo studies have demonstrated that magnesium enhances the local anesthetics effect on peripheral nerves . No previous studies were conducted on magnesium sulfate as an adjuvant to the local anesthetic in genicular nerve block. Hence, this study will be conducted to assess analgesic efficacy of magnesium sulfate when added to bupivacaine in ultrasound guided genicular nerve block

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * American Society of Anesthesiologist (ASA) I or II physical status. * Between 18 and 70 years of age. * Both genders. * Patients undergoing total knee replacement surgery. Exclusion Criteria: * Patient refusal. * ASA Ⅲ and Ⅳ patients. * Known allergy to the study drugs. * Hypermagnesemia. * Central or peripheral neurological disease. * Pregnancy. * Drug or alcohol abuse. * Localized infection at the site of the block. * Bleeding disorder (platelets count less than 100,000 or international normalized ratio more than 1.4)

What they're measuring

Numerical Rating Scale

Timeframe: 24 hours post-operatively

Trial details

NCT IDNCT06520475

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-09-15

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