Not Yet RecruitingNot Applicable

Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients

30 participantsStarted 2024-08-01

Plain-language summary

The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on patients with ventilator-induced diaphragmatic dysfunction (VIDD).

Who can participate

Age range

20 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Age (years) Weight (kg) Height (cm) BMI (kg/m²) Inclusion Criteria: * Patients who had undergone MV for 48 hours or more in a controlled mode. * Patients could not generate maximum inspiratory pressure of more than 15 mbar * Patients had diaphragmatic excursion less than 3 cm. (normal level from 3 to 5 cm.)(It can increase in a condition person to 7-8 cm). * Patients had a diaphragmatic thickness fraction of less than 30% Exclusion Criteria: * Patients with comorbidities interfering and compromising weaning like cardiac arrhythmia, pericardial effusion, congestive heart failure, or unstable acute coronary syndrome. * Patients who had inadequate training performance of the inspiratory muscle such as those having myopathy or neuropathy. * Patients hemodynamically unstable. * Patients who had a major neurological deficit. * Sedated Patients.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Vital signs

Timeframe: one week

Respiratory rate RR/min

Timeframe: one week

Blood Pressure mmHg

Timeframe: one week

Arterial blood gases (ABG):-

Timeframe: one week

PCO2 mmHg

Timeframe: one week

HCO3 mEQ/Liter

Timeframe: one week

PSAO2 mmHg

Timeframe: one week

Trial details

NCT IDNCT06515600

SponsorSouth Valley University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-10-01

View on ClinicalTrials.gov More Ventilator-Induced Diaphragmatic Dysfunction trials

Who can participate

Age range

20 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.