CompletedPhase 4

Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General Anesthesia

China136 participantsStarted 2023-02-01

Plain-language summary

Purpose: This study aims to compare the emergence time among three anesthesia regimens: remimazolam, remimazolam with flumazenil, and propofol in elderly patients undergoing hip replacement surgery. Background: Previous studies have shown that flumazenil accelerates emergence time when used with remimazolam. Remimazolam and propofol have comparable emergence times, although remimazolam can be up to 5 minutes longer than propofol.

Who can participate

Age range65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Elderly patients (≥65 years old). * Scheduled for elective hip replacement surgery. * ASA (ASA, American Society of Anesthesiologists) physical status I-III. * Able to provide informed consent. Exclusion Criteria: * Known hypersensitivity to remimazolam, flumazenil, or propofol. * Severe hepatic or renal impairment. * History of benzodiazepine or alcohol abuse. * Cognitive impairment that may interfere with the ability to provide consent.

What they're measuring

Time to Emergence

Timeframe: Within one day of surgery

Trial details

NCT IDNCT06513923

SponsorCentral South University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-30

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