Not Yet RecruitingNot Applicable

10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery

Egypt184 participantsStarted 2024-08

Plain-language summary

Data regarding the optimum dose of norepinephrine for management of severe maternal hypotension is lacking. A previous report showed that the use of 10-mcg norepinephrine bolus was not superior to the 5-mcg bolus in the management of severe hypotension in addition the incidence of reactive bradycardia and hypertension was comparable in the two doses. Therefore, we hypothesize that using a higher dose of norepinephrine (15 mcg) would increase the success rate of management of severe hypotensive episode.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * full-term singleton pregnant women * American society of anesthesiologist II, scheduled for elective cesarean delivery, Exclusion Criteria: * Patients with uncontrolled cardiac morbidities (patients with tight valvular lesion, impaired contractility with ejection fraction \< 50%, heart block, and arrhythmias), * hypertensive disorders of pregnancy, * peripartum bleeding, * coagulation disorders (patients with INR \>1.4 and or platelet count \< 80000 /dL) or any contraindication to regional anesthesia, * baseline systolic blood pressure (SBP) \< 100 mmHg

What they're measuring

the incidence of successful management of severe post-spinal hypotension

Timeframe: 1 min after spinal anesthesia until 5 min after the delivery

Trial details

NCT IDNCT06512415

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12

View on ClinicalTrials.gov More Hypotension trials