Not Yet RecruitingNot Applicable

Heparin Alone vs. Heparin-Aspirin Combo in Free Flap Survival

Pakistan126 participantsStarted 2025-01

Plain-language summary

This randomized clinical trial aims to compare the effectiveness of heparin alone versus combination therapy of Heparin- Aspirin in improving free flap survival in patients undergoing reconstructive surgery. Participants will be randomly assigned to receive either heparin or a combination therapy, and the primary outcome measure will be the survival rate of the free flap at various time points post-surgery

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients undergoing free flap surgery * Age between 18 and 70 years Exclusion Criteria: * Known hypersensitivity to heparin or aspirin * History of bleeding disorders * Concurrent use of other anticoagulant or antiplatelet medications * Severe renal or hepatic impairment * Preoperative use of aspirin that could not be stopped five days before surgery due to a higher risk of cardiac-related complications.

What they're measuring

Free Flap Survival Rate

Timeframe: two hourly for 1st 24 hours and then three hourly for next 48 hours and four hourly for next 72 hours and onwards.

Trial details

NCT IDNCT06512233

SponsorAga Khan University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12

Contact for this trial

Fizzah Arif, MD

+92 336 2230665 fizzah.arif@aku.edu

View on ClinicalTrials.gov More Complication,Postoperative trials