Exercise, Brain Activity, and Weight Maintenance

Inclusion Criteria: * Age 18-70 years * Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg * Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference. * In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations * Willing to adhere to the protocol requirements for the duration of the study Exclusion Criteria: * Type 1 diabetes mellitus * Peripheral neuropathy with insensate feet * Recent blood donation within the last 2 months * Use of beta-blockers * Current pregnancy or breastfeeding * Active Heart or lung disease * Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg) * Inability to exercise for any reason * Any known contraindication to exercise testing based on current ACSM guidelines * MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body * Known presence of a structural brain lesion (e.g. tumor, cortical infarct) * Presence of another neurologic disorder, …