RecruitingNot Applicable

Blood Flow Restriction for Optimizing Balance in Parkinson's Disease

United States20 participantsStarted 2025-01-07

Plain-language summary

This study is being done to understand how reducing blood flow (BRT) during balance-challenging strengthening exercises (instability resistance training, or IRT) can help improve symptoms of Parkinson's disease.

Who can participate

Age range40 Years – 85 Years

SexALL

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Inclusion criteria

✓. Males and females between the ages 40 - 85 with a diagnosis of idiopathic Parkinson's Disease (PD) consistent with the United Kingdom PD society brain bank criteria,
✓. in Hoehn and Yahr stage 2-4,
✓. a score of ≥23 on the mini-Mental Scale Examination.

Exclusion criteria

✕. History of cardiovascular disease, uncontrolled hypertension (blood pressure ≥140/90 mmHg), orthostatic hypotension, deep-vein thrombosis, varicose veins, or rhabdomyolysis;
✕. Ankle branchial index ≤ 0.9 or \> 1.3.
✕. History of other neurological disorders affecting the central nervous system such as stroke, multiple sclerosis, tumors, amyotrophic lateral sclerosis or muscle disease such as muscular dystrophy, myopathy.
✕. History of uncontrolled diabetes, severe osteoporosis, or cognitive impairment.
✕. Body mass index above 40; such individuals are more likely to have poorer muscle function and more pain.
✕. Absolute contraindications to exercise as per the American College of Sports Medicine (uncontrolled arrhythmias, third-degree heart block, recent electrocardiogram (EKG) changes, unstable angina, acute myocardial infarction, or acute congestive heart failure
✕. Had surgery in the lower extremities within the past 6 months.
✕. Pre-menopausal and not on birth control

What they're measuring

Feasibility metric

Timeframe: Baseline to 6 weeks

Trial details

NCT IDNCT06508801

SponsorThe University of Texas Health Science Center at San Antonio

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

Contact for this trial

Anjali Sivaramakrishnan, PhD, PT

210-567-8626 sivaramakris@uthscsa.edu

View on ClinicalTrials.gov More Parkinson's Disease and Parkinsonism trials