RecruitingNot Applicable

Nausea Induced by Radiation of the Dorsal Vagal Complex for Benign Brain Tumors (NausiCAA)

France100 participantsStarted 2022-05-20

Plain-language summary

Patients irradiated to the brain frequently experience nausea. The dorsal vagal complex (DVC) area is a specific brainstem zone and has been identified as likely responsible for nausea. Existing clinical studies show correlation between dose to the DVC and nausea, but they concern tumors of the airways and upper digestive tract, where there are many confounding factors. The aim of this study is to establish a ling between radiation dose to the DVC and nausea. Defining a dose threshold to the DVC will allow radiation oncologists to optimize radiation dose distribution and reduce nausea in patients.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * More than 18 years old * With benign brain tumor * Irradiated with conventional fractionation (1,8-2Gy/fraction) Exclusion Criteria: * History of brain radiation * History of head and neck radiation * Demencia * Concurrent chemotherapy * Nausea at the time of inclusion * Anti-nausea treatment : corticosteroids, metoclopramide, setrons, other

What they're measuring

Functional Living Index-Emesis (FLIE score)

Timeframe: At inclusion, at day 35 of radiotherapy, at 1 and 3 months after completion of radiotherapy

Trial details

NCT IDNCT06506578

SponsorUniversity Hospital, Bordeaux

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-06

Contact for this trial

Charles DUPIN, MD, PhD

:+33(0)557623310 charles.dupin@chu-bordeaux.fr

View on ClinicalTrials.gov More Benign Brain Tumor trials